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A novel method based on atomic force microscopy (AFM) working in Ringing mode (RM) to distinguish between two similar human colon epithelial cancer cell lines that exhibit different degrees of neoplastic aggressiveness is reported on. The classification accuracy in identifying the cell line based on the images of a single cell can be as high … Read more

We report an approach in diagnostic imaging based on nanoscale-resolution scanning of surfaces of cells collected from body fluids using a recent modality of atomic force microscopy (AFM), subresonance tapping, and machine-leaning analysis. The surface parameters, which are typically used in engineering to describe surfaces, are used to classify cells. The method is applied to … Read more

The atomic force microscope is broadly used to study the morphology of cells1–5 but it can also probe the mechanics of cells. It is now known that cancerous cells may have different mechanical properties than normal cells6–8 but the reasons for these differences are poorly understood9. Here we report quantitatively the differences between normal and cancerous human … Read more